manufective technologies
Sustainable Solutions require No-Regret-Solutions


"Personalized Medicine - Revolutionizing Process Development and Manufacturing of Drugs"

Dr. Helmut Mothes -

Personalized Medicine represents a major paradigm change for the Healthcare Industry.Therapy in Conventional Medicine is based on the assumption that a general drugapplied properly could serve all patients. Therapy in Personalized Medicine isbased on phenotype, genotype and other features of an individual patient orpatient collective. It is clear that in order to meet the future needs of PersonalizedMedicine, a new production system will emerge:

  1. Personalized Medicine requires drugs tailor-made for patient sub groups / individuals.
  2. Drug design could become part of themanufacturing process.
  3. PersonalizedMedicine leads compared to today to more small-quantity drugs (instead ofblockbuster drugs), more slightly modified drug varieties forpersonalization and various drug delivery/packaging systems (doseadjusted).
  4. Personalized Medicine, therefore, requires a very flexible, small-volume production with intensified, dedicated unit operations, modular equipment assemblies and highly automated, flexible assembly-lines.

Currently drugs are mainly produced in multi-purpose/multi-product facilities in a batch operation. Overall processing time of drug takes several months requiring a complex global supply chain. This is no longer economical even for conventional drugs – in any case prohibitive for small volume, tailor-made personalized medicine drugs.A new production paradigm will be required for personalized medicine drugs combining process intensification concepts, novel technologies and a new operation mode. Processing industry-type manufacturing will be replaced by assembly-line-type factories - fully automated and dedicated to a certain drug. The drug design process will even become an integral part of the manufacturing process.

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